Naltrexone Offers Hope for Alcohol Use Disorder
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Naltrexone Offers Hope for Alcohol Use Disorder
- Naltrexone, a medication approved by the FDA, has shown positive outcomes for 73% to over 80% of participants with alcohol use disorder in clinical trials.
- The Sinclair Method, which involves taking naltrexone before drinking, has reported approximately a 78% reduction in alcohol consumption over time.
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Naltrexone is a prescription medication used to treat alcohol use disorder (AUD) and opioid use disorder. It works by blocking opioid receptors in the brain, which reduces cravings for alcohol and diminishes the “reward” or pleasurable feelings associated with drinking. This can make it easier for individuals to cut back on their alcohol consumption or achieve abstinence.
The medication is available in oral tablet form, typically taken daily, and as an extended-release injectable form administered once a month. Oral naltrexone without insurance can cost between $25 and $108 for a 30-day supply of 50 mg tablets. Some pharmacies and discount programs may offer it for as low as $0.64 per tablet for a supply of 90 tablets, or around $37 for 30 tablets with a coupon.
Clinical trials have consistently demonstrated naltrexone’s effectiveness, with success rates ranging from 73% to over 80% for individuals with AUD. The COMBINE study, a large clinical trial, showed a 73.7% “good clinical outcome” for participants receiving naltrexone. Another approach, known as the Sinclair Method, involves taking naltrexone an hour before drinking, which has been associated with a 78% reduction in alcohol consumption.
Naltrexone is not a cure for alcoholism but is considered a beneficial tool when used as part of a comprehensive treatment plan that often includes counseling and support groups. It is not addictive and does not cause withdrawal symptoms if stopped. However, individuals should